應用分類
Whole Transcriptome
Parse Evercode™ split-pool combinatorial barcoding is a simple, instrument-free workflow that converts the cell or nucleus into an individual reaction compartment. This easily adopted approach brings unprecedented sensitivity, scalability, and flexibility to any lab.
Combinatorial barcoding with Evercode™
Reverse
Transcription
Ligation
Ligation
Lysis+PCR
Library Prep
Immune Profilling
Evercode™ TCR / BCR
Capture paired TCRs / orfull length BCR and gene expression from the same cell at unprecedented scale
Reveal the complexity of the immune repertoire with sensitive detection of TCRs or BCRs. Measure transcriptome-wide gene expression (including key T-cell subtype markers) together with paired alpha and beta sequences, or full-length paired heavy and light sequences and isotypes in the same cells.
Sample Preparation
Levitation Technology™ is the first truly novel approach to cellular analysis in 30 years. Extensive research has shown that cells of different types or states have unique physical signatures, levitating in predictable ways when they encounter a magnetic density field.
scDNA + Protein
Oncology Research
The heterogeneity and dynamism of cancer present formidable challenges to treating the disease. Through an iterative process of mutation and cell expansion, tumors generate genetic and phenotypic heterogeneity, contributing to the complexity of the disease.
scDNA AML MRD panel
The complexity of leukemia clonal architecture and the genotypic and phenotypic drifts during treatment explain why more than half of patients in remission could relapse. Addressing these with single-cell multiomics enables you to go beyond a binary MRD readout to gain crucial biomarker insights.
Precision Medicine
Resolving complex biology at the single cell level is crucial to the understanding of disease and ultimately unlocking novel therapies. While advances have been made in precision medicine, challenges in fully understanding disease profiles at the clonal level and comprehensive characterization of ex vivo cell therapeutics remain.
Genome Editing
Genome engineering techniques, like CRISPR, result in heterogeneous editing outcomes that include variations in zygosity, off-target effects, co-occurring multiplex edits, chromosomal translocations, and changes to genome stability. Measuring these outcomes accurately cannot be done by traditional sequencing without lengthy clonal outgrowth steps and hours of computational work.
Genome integrity
Genome integrity is essential for predicting therapeutic safety and patient outcomes, whether dealing with cell-based therapies or analyzing heterogeneous tumors. Traditional methods for assessing genome stability are often limited by low throughput or time-consuming clonal outgrowth processes.